Intravascular large B cell lymphoma limited in renal glomaruli: A case presented as nephrotic syndrome

Yingxue Cao, Zhuxing Sun, Liang Wang, Jia Hua, Shaojun Liu, Chuan-Ming Hao


Intravascular large B cell lymphoma (IVLBCL) is a rare type of non-Hodgkin lymphoma, characterized by selective proliferation of B cells within the lumens of small vessels. We report a case of IVLBCL with the invaded B cells limited in the lumen of glomerular capillary loops. The patient presented with nephrotic syndrome. Histological examination of renal biopsy specimens showed infiltration of neoplastic cells limited in glomerular capillary loops, accompanied by diffuse foot process effacement only in those capillary loops with the infiltrative cells. Immunohistochemistry shows that the infiltrative cells were positive for bcl-2, bcl-6, CD20, MUM1 and ki-67, consistent with atypical cells deriving from B cells. Unfortunately, the patient refused the further treatment and died soon after the diagnosis.

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Case Reports in Internal Medicine

ISSN 2332-7243(Print)  ISSN 2332-7251(Online)

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