Omental gastrointestinal stromal tumor: Arriving at a diagnosis with therapeutic options in the molecular era

Michael P. Greenwood, F. Jariel Hairston, Mary R. Schwartz, Kristi Pepper, Heather Hendrickson, Anuj Suri, Donna Coffey, Michael Deavers, Randall J. Olsen, Jessica S. Thomas


Omental extragastrointestinal stromal tumors are rare neoplasms. We present a case of an elderly woman who was found to have a large solid and cystic pelvic mass of presumed ovarian origin with associated omental neovascularity. Histopathologic examination showed a mixed spindled and epithelioid tumor which was essentially negative for c-KIT and positive for smooth muscle markers by immunohistochemistry. A next generation sequencing panel was performed, analyzing the patient’s tumor for actionable mutations in 50 genes commonly associated with human cancers. Identification of a point mutation in PDGFRA enabled accurate diagnosis and provided an option for targeted therapy for this rare tumor.

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Case Reports in Clinical Pathology

ISSN 2331-2726(Print)  ISSN 2331-2734(Online)

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