A case of atypical Takayasu arteritis initially presenting with peripheral artery disease

Hiroshi Kawano, Masaki Hanibuchi, Terumi Yoshijima, Yuko Toyoda, Jun Kishi, Toshifumi Tezuka, Yasuhiko Nishioka


A 28-year-old woman developed Raynaud’s phenomenon and sudden left visual loss due to hypertensive retinopathy. One and a half years later, she noticed peripheral coldness and numbness of right foot. Enhanced computed tomography showed remarkable stenosis of left radial and bilateral tibial arteries. Initially, the diagnosis of idiopathic peripheral arterial occlusive disease (PAD) was made. PAD gradually progressed despite the medication with antiplatelet drug and vasodilator, and coronary angiography revealed a left coronary artery aneurysm. Then, she developed the same ischemic symptom of right hand and left visual loss caused by papilledema. Although 18F-fluorodeoxyglucose positron-emission tomography showed no abnormalities, and both HLA-B52 and HLA-B39 were negative, she was diagnosed with atypical Takayasu arteritis (TA) by exclusion of other possible diseases. To the best of our knowledge, this is the first case of TA with coronary aneurysm and PAD. In TA patients, the involvement of medium-sized vascular lesion such as peripheral extremity arteries should be considered.

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DOI: https://doi.org/10.5430/crcp.v2n2p34


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Case Reports in Clinical Pathology

ISSN 2331-2726(Print)  ISSN 2331-2734(Online)

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