Isolated intestinal manifestation of graft-versus-host disease following renal transplantation

Michael Praktiknjo, Dominik Boes, Michael Majores, Christian Strassburg, Rainer Woitas


Graft-versus-host disease (GVHD) is a potentially lethal complication commonly occurring after hematopoietic stem cell transplantation and non-irradiated blood cell transfusion in patients with underlying immunodeficiency. In solid organ transplantation GVHD however is a rarity. There have been four cases of GVHD after renal transplantation, most of them with fulminant systemic clinical manifestation and mostly associated with blood transfusions. We report the first case of a four HLA-antigen mismatched kidney transplant patient who presented with diarrhea due to intestine-only manifestation of GVHD and was treated successfully with quadruple immunosuppression.

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Case Reports in Internal Medicine

ISSN 2332-7243(Print)  ISSN 2332-7251(Online)

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