All-trans retinoic acid-induced myositis during treatment of acute promyelocytic leukemia

Mayorga-Bajo I, Ortega-Valín L, Fuertes M, Ramos F


A 47-year-old man, newly diagnosed with acute promyelocytic leukemia was treated with all-trans retinoic acid (ATRA) and idarrubicin. On day +24, he presented with fever and swelling in the left lower limb. The US and MRI were compatible with a myositis of tibialis anterior, later confirmed by muscle biopsy. ATRA-induced myositis was suspected. On day +29, ATRA was discontinued and the patient treated with dexamethasone. The patient improved promptly and ATRA was administered thereafter without any myositis relapse. The Naranjo scale indicated a probable relationship between ATRA and myositis. We herein review the published cases. Re-exposition to the drug seems to be safe for the patient.

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Case Reports in Internal Medicine

ISSN 2332-7243(Print)  ISSN 2332-7251(Online)

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