Acute ophthalmoplegia without ataxia associated with anti-GQ1b antibody in a Chinese Gentleman

Helen LK Yip, MC Kwan, WK Cheng, WY Lau


Miller Fisher first described three patients who suffered from acute neurological illness characterized by ophthalmoplegia, areflexia and ataxia. It is considered to be a subtype of Guillain Barre Syndrome. While another subtype of GBS without ataxia was first described by Chiba et al. and is associated with isolated acute ophthalmoplegia with raised anti-GQ1b Immunoglobulin G (IgG) antibody in early phase of illness. We report a Chinese patient who presented with acute ophthalmoplegia without ataxia nor limb weakness with strongly positive anti-GQ1b IgG antibody.  His neurological symptoms improved after a course of intravenous immunoglobulin (IVIg) therapy.

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Case Reports in Internal Medicine

ISSN 2332-7243(Print)  ISSN 2332-7251(Online)

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